The field of quantum computing is on the brink of transformative advancements, driven by tangible progress in hardware development. As we are entering the era of pre-fault tolerant quantum devices, the potential for addressing complex quantum systems, once confined to theoretical realms, is becoming increasingly concrete. This conference aims to foster a collaborative environment where scientists from diverse backgrounds, including large-scale quantum experiments, classical approximation methods, and quantum algorithms, can come together to explore the implications of this hardware progress. By facilitating interdisciplinary discussions and knowledge sharing, we seek to identify critical challenges and opportunities in leveraging pre-fault tolerant quantum hardware to tackle complex problems in quantum physics, chemistry, materials science, and beyond.